Biochemical and functional characterization of Parawixia bistriata spider venom with potential proteolytic and larvicidal activities.

ABSTRACT: Toxins purified from the venom of spiders have high potential to be studied pharmacologically and biochemically. These biomolecules may have biotechnological and therapeutic applications. This study aimed to evaluate the protein content of Parawixia bistriata venom and functionally characterize its proteins that have potential for biotechnological applications. The crude venom showed no phospholipase, hemorrhagic, or anti-Leishmania activities attesting to low genotoxicity and discrete antifungal activity for C. albicans. However the following activities were observed: anticoagulation, edema, myotoxicity and proteolysis on casein, azo-collagen, and fibrinogen. The chromatographic and electrophoretic profiles of the proteins revealed a predominance of acidic, neutral, and polar proteins, hi

SUBMITTER: Gimenez GS 

PROVIDER: S-EPMC4033418 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature