LncRNAs expression signatures of hepatocellular carcinoma revealed by microarray.

ABSTRACT:

Aim

To analyze the expression profiles of long non-coding RNAs (lncRNAs) in hepatocellular carcinoma.

Methods

Hepatocellular carcinoma (HCC) tissues and matched adjacent non-tumor (NT) liver tissues were collected from 29 patients with HCC, immediately after liver resection, between March 2011 and July 2013. The diagnosis of HCC was made based on histological examination. Differentially expressed lncRNAs between HCC and NT tissues were revealed through microarray-based lncRNAs expression profiling. Further, quantification of selected lncRNAs was performed using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR).

Results

Six hundred and fifty-nine lncRNAs were differentially expressed between HCC and NT tissues, of which five [TCONS_000182

SUBMITTER: Liu WT 

PROVIDER: S-EPMC4033470 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature