Temporal regulation of Dpp signaling output in the Drosophila wing.

ABSTRACT:

Background

The Decapentaplegic (Dpp) signaling pathway is used in many developmental and homeostatic contexts, each time resulting in cellular responses particular to that biological niche. The flexibility of Dpp signaling is clearly evident in epithelial cells of the Drosophila wing imaginal disc. During larval stages of development, Dpp functions as a morphogen, patterning the wing developmental field and stimulating tissue growth. A short time later, however, as wing-epithelial cells exit the cell cycle and begin to differentiate, Dpp is a critical determinant of vein-cell fate. It is likely that the Dpp signaling pathway regulates different sets of target genes at these two developmental time points.

Results

To identify mechanisms that temporally control the transcriptio

SUBMITTER: O'Keefe DD 

PROVIDER: S-EPMC4034111 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature