Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection.

ABSTRACT: CD4 T cells are central to orchestrate, sustain, and potentially regenerate antiviral immunity throughout persistent viral infections. Although the evolving immune environment during persistent infection reshapes established CD4 T-cell responses, the fate of naïve CD4 T cells primed in the midst of persistent infection is unclear. We demonstrate that, in marked contrast to the onset of infection, virus-specific CD4 T cells primed during an established persistent infection have diminished ability to develop Th1 responses, to efficiently accumulate in peripheral tissues, and almost exclusively differentiate into T follicular helper cells. Consistent with suppressed Th1 and heightened Tfh differentiation, virus-specific CD4 T cells primed during the established persistent infection provide he

SUBMITTER: Osokine I 

PROVIDER: S-EPMC4034239 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature