Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche.

ABSTRACT: The erythroblastic island provides an important nutritional and survival support niche for efficient erythropoietic differentiation. Island integrity is reliant on adhesive interactions between erythroid and macrophage cells. We show that erythroblastic islands can be formed from single progenitor cells present in differentiating embryoid bodies, and that these correspond to erythro-myeloid progenitors (EMPs) that first appear in the yolk sac of the early developing embryo. Erythroid Krüppel-like factor (EKLF; KLF1), a crucial zinc finger transcription factor, is expressed in the EMPs, and plays an extrinsic role in erythroid maturation by being expressed in the supportive macrophage of the erythroblastic island and regulating relevant genes important for island integrity within these cell

SUBMITTER: Xue L 

PROVIDER: S-EPMC4034424 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature