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Carpatamides A-C, cytotoxic arylamine derivatives from a marine-derived Streptomyces sp.

ABSTRACT: Three new acylated arylamine derivatives (1-3), carpatamides A-C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1-3 were established on the basis of comprehensive spectroscopic analyses and chemical methods. Compounds 1 and 3 showed moderate cytotoxicity against NSCLC cell lines HCC366, A549, and HCC44 with IC50 values ranging from 2.2 to 8.4 ?M.

SUBMITTER: Fu P 

PROVIDER: S-EPMC4035114 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Carpatamides A-C, cytotoxic arylamine derivatives from a marine-derived Streptomyces sp.

Fu Peng P   Johnson Melissa M   Chen Hong H   Posner Bruce A BA   MacMillan John B JB  

Journal of natural products 20140423 5

Three new acylated arylamine derivatives (1-3), carpatamides A-C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1-3 were established on the basis of comprehensive spectroscopic analyses and chemical methods. Compounds 1 and 3 showed moderate cytotoxicity against NSCLC cell lines HCC366, A549, and HCC44 with IC50 values ranging from 2.2 to 8.4 μM. ...[more]

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