Network analyses reveal pervasive functional regulation between proteases in the human protease web.

ABSTRACT: Proteolytic processing is an irreversible posttranslational modification affecting a large portion of the proteome. Protease-cleaved mediators frequently exhibit altered activity, and biological pathways are often regulated by proteolytic processing. Many of these mechanisms have not been appreciated as being protease-dependent, and the potential in unraveling a complex new dimension of biological control is increasingly recognized. Proteases are currently believed to act individually or in isolated cascades. However, conclusive but scattered biochemical evidence indicates broader regulation of proteases by protease and inhibitor interactions. Therefore, to systematically study such interactions, we assembled curated protease cleavage and inhibition data into a global, computational repres

SUBMITTER: Fortelny N 

PROVIDER: S-EPMC4035269 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature