Integration of mRNA expression profile, copy number alterations, and microRNA expression levels in breast cancer to improve grade definition.

ABSTRACT: Defining the aggressiveness and growth rate of a malignant cell population is a key step in the clinical approach to treating tumor disease. The correct grading of breast cancer (BC) is a fundamental part in determining the appropriate treatment. Biological variables can make it difficult to elucidate the mechanisms underlying BC development. To identify potential markers that can be used for BC classification, we analyzed mRNAs expression profiles, gene copy numbers, microRNAs expression and their association with tumor grade in BC microarray-derived datasets. From mRNA expression results, we found that grade 2 BC is most likely a mixture of grade 1 and grade 3 that have been misclassified, being described by the gene signature of either grade 1 or grade 3. We assessed the potential of th

SUBMITTER: Cava C 

PROVIDER: S-EPMC4035288 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature