Laparoscopic radiofrequency fibroid ablation: phase II and phase III results.

ABSTRACT:

Background and objectives

To review phase II and phase III treatments of symptomatic uterine fibroids (myomas) using laparoscopic radiofrequency volumetric thermal ablation (RFVTA).

Methods

We performed a retrospective, multicenter clinical analysis of 206 consecutive cases of ultrasound-guided laparoscopic RFVTA of symptomatic myomas conducted on an outpatient basis under two phase II studies at 2 sites (n = 69) and one phase III study at 11 sites (n = 137). Descriptive and exploratory, general trend, and matched-pair analyses were applied.

Results

From baseline to 12 months in the phase II study, the mean transformed symptom severity scores improved from 53.9 to 8.8 (P < .001) (n = 57), health-related quality-of-life scores improved from 48.5 to 92.0 (P < .001) (n =

SUBMITTER: Galen DI 

PROVIDER: S-EPMC4035627 | biostudies-literature | 2014 Apr-Jun

REPOSITORIES: biostudies-literature