Effects of established BMI-associated loci on obesity-related traits in a French representative population sample.

ABSTRACT:

Background

Genome-wide association studies have identified variants associated with obesity-related traits, such as the body mass index (BMI). We sought to determine how the combination of 31 validated, BMI-associated loci contributes to obesity- and diabetes-related traits in a French population sample. The MONA LISA Lille study (1578 participants, aged 35-74) constitutes a representative sample of the population living in Lille (northern France). Genetic variants were considered both individually and combined into a genetic predisposition score (GPS).

Results

Individually, 25 of 31 SNPs showed directionally consistent effects on BMI. Four loci (FTO, FANCL, MTIF3 and NUDT3) reached nominal significance (p ≤ 0.05) for their association with anthropometric traits. When consid

SUBMITTER: Goumidi L 

PROVIDER: S-EPMC4035696 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature