Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease.

ABSTRACT:

Objective

To examine whether β-amyloid (Aβ) and APOE ε4 status independently contribute or interact to influence longitudinal cognitive decline in clinically normal older individuals (CN).

Methods

Data from 490 CNs were aggregated across 3 observational cohort studies (Harvard Aging Brain Study, Alzheimer's Disease Neuroimaging Initiative, and Australian Imaging Biomarkers and Lifestyle Study of Ageing; median age = 75.0 years, 255 female), and the contributions of APOE ε4 and Aβ on longitudinal change over a median of 1.49 years were examined. Cognitive decline was assessed with the Mini-Mental State Examination (MMSE) and Logical Memory (immediate and delayed recall scores).

Results

High Aβ participants were more likely to be APOE ε4+ than low Aβ participants. CNs w

SUBMITTER: Mormino EC 

PROVIDER: S-EPMC4035706 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature