Longitudinal follow-up of SWEDD subjects in the PRECEPT Study.

ABSTRACT:

Objective

To compare the clinical and imaging characteristics of those PRECEPT (Parkinson Research Examination of CEP-1347 Trial) subjects with a scan without evidence of dopaminergic deficit (SWEDD) to those with dopamine transporter (DAT) deficit scans at study baseline and during a 22-month follow-up.

Methods

Baseline (n = 799) and 22-month follow-up (n = 701) [(123)I] β-CIT SPECT scans were acquired. The percent change in [(123)I] β-CIT striatal binding ratio, the percentage of subjects requiring dopaminergic therapy, the change in Unified Parkinson's Disease Rating Scale (UPDRS) score, and the PRECEPT Study investigators' diagnosis at study termination were compared between SWEDD and DAT deficit subjects.

Results

SWEDD subjects (n = 91) compared with DAT deficit

SUBMITTER: Marek K 

PROVIDER: S-EPMC4035714 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature