Functional characterization of a Na+-dependent dicarboxylate transporter from Vibrio cholerae.

ABSTRACT: The SLC13 transporter family, whose members play key physiological roles in the regulation of fatty acid synthesis, adiposity, insulin resistance, and other processes, catalyzes the transport of Krebs cycle intermediates and sulfate across the plasma membrane of mammalian cells. SLC13 transporters are part of the divalent anion:Na(+) symporter (DASS) family that includes several well-characterized bacterial members. Despite sharing significant sequence similarity, the functional characteristics of DASS family members differ with regard to their substrate and coupling ion dependence. The publication of a high resolution structure of dimer VcINDY, a bacterial DASS family member, provides crucial structural insight into this transporter family. However, marrying this structural insight to the

SUBMITTER: Mulligan C 

PROVIDER: S-EPMC4035743 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature