Genetic variants at chromosome 9p21 and risk of first versus subsequent coronary heart disease events: a systematic review and meta-analysis.

ABSTRACT:

Objectives

The purpose of this analysis was to compare the association between variants at the chromosome 9p21 locus (Ch9p21) and risk of first versus subsequent coronary heart disease (CHD) events through systematic review and meta-analysis.

Background

Ch9p21 is a recognized risk factor for a first CHD event. However, its association with risk of subsequent events in patients with established CHD is less clear.

Methods

We searched PubMed and EMBASE for prospective studies reporting association of Ch9p21 with incident CHD events and extracted information on cohort type (individuals without prior CHD or individuals with established CHD) and effect estimates for risk of events.

Results

We identified 31 cohorts reporting on 193,372 individuals. Among the 16 cohort

SUBMITTER: Patel RS 

PROVIDER: S-EPMC4035794 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature