Ontology highlight
ABSTRACT:
SUBMITTER: Ramsey IS
PROVIDER: S-EPMC4035905 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Ramsey I Scott IS Mokrab Younes Y Carvacho Ingrid I Sands Zara A ZA Sansom Mark S P MSP Clapham David E DE
Nature structural & molecular biology 20100613 7
Hv1 voltage-gated proton channels mediate rapid and selective transmembrane H(+) flux and are gated by both voltage and pH gradients. Selective H(+) transfer in membrane proteins is commonly achieved by Grotthuss proton 'hopping' in chains of ionizable amino acid side chains and intraprotein water molecules. To identify whether ionizable residues are required for proton permeation in Hv1, we neutralized candidate residues and measured expressed voltage-gated H(+) currents. Unexpectedly, charge n ...[more]