Ontology highlight
ABSTRACT:
SUBMITTER: Ma X
PROVIDER: S-EPMC4035923 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Ma Xin X Chen Zhen Z Hua Dong D He Dongxu D Wang Linjun L Zhang Peng P Wang Junqi J Cai Yanfei Y Gao Caiji C Zhang Xiaodong X Zhang Fangfang F Wang Teng T Hong Tingting T Jin Linfang L Qi Xiaowei X Chen Shuxian S Gu Xiaoting X Yang Dangtong D Pan Qiongxi Q Zhu Yifei Y Chen Yun Y Chen Daozhen D Jiang Liwen L Han Xiaofeng X Zhang Yanyun Y Jin Jian J Yao Xiaoqiang X
Proceedings of the National Academy of Sciences of the United States of America 20140414 17
A critical challenge for chemotherapy is the development of chemoresistance in breast cancer. However, the underlying mechanisms and validated predictors remain unclear. Extracellular vesicles (EVs) have gained attention as potential means for cancer cells to share intracellular contents. In adriamycin-resistant human breast cancer cells (MCF-7/ADM), we analyzed the role of transient receptor potential channel 5 (TrpC5) in EV formation and transfer as well as the diagnostic implications. Up-regu ...[more]