Homeostasis of functional maps in active dendrites emerges in the absence of individual channelostasis.

ABSTRACT: The maintenance of ion channel homeostasis, or channelostasis, is a complex puzzle in neurons with extensive dendritic arborization, encompassing a combinatorial diversity of proteins that encode these channels and their auxiliary subunits, their localization profiles, and associated signaling machinery. Despite this, neurons exhibit amazingly stereotypic, topographically continuous maps of several functional properties along their active dendritic arbor. Here, we asked whether the membrane composition of neurons, at the level of individual ion channels, is constrained by this structural requirement of sustaining several functional maps along the same topograph. We performed global sensitivity analysis on morphologically realistic conductance-based models of hippocampal pyramidal neurons t

SUBMITTER: Rathour RK 

PROVIDER: S-EPMC4035944 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature