Enhanced evolution by stochastically variable modification of epigenetic marks in the early embryo.

ABSTRACT: Evolution by gene duplication is generally accepted as one of the crucial driving forces for the gain of new complexity and functions, but the formation of pseudogenes remains a problem for this mechanism. Here we expand on earlier ideas that epigenetic modifications can drive neo- and subfunctionalization in evolution by gene duplication. We explore the effects of stochastic epigenetic modifications on the evolution (and thus development) of complex organisms in a constant environment. Modeling is done both using a modified genetic drift analytical treatment and computer simulations, which were found to agree. A transposon silencing model is also explored. Some key assumptions made include (i) stochastic, incomplete removal (or addition) of repressive epigenetic marks takes place during a

SUBMITTER: Branciamore S 

PROVIDER: S-EPMC4035958 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature