Project description:Purpose: To search candidate synergized compounds from Chinese herbal medicine used in RA therapy Methods: Candidate synergized compounds were searched based on multi-information integrative approaches. In vivo experiment in collagen induced arthritis rat was then carried out to evaluate the efficacy and synergism of compounds combination treatment. RNA sequencing and IPA were used to investigate the synergized mechanism of combination treatment. Results: We found a pair of compound combination which could alleviate the symptom of CIA rats. RNA sequencing and IPA analysis revealed that the synergistic mechanism of combination treatment was related to several canonical signaling pathways and key targets LTA, CD83 and SREBF1. Conclusion: A pair of compound combination has been found. RNA sequencing and IPA analysis revealed that the synergistic mechanism of combination treatment was related to several canonical signaling pathways and key targets.

2021-09-20 | GSE148598 | GEO

Understanding Chinese Medicine Patterns of Rheumatoid Arthritis and Related Biomarkers.

Project description: Not available

| S-EPMC5874582 | biostudies-literature

Sleep Matters: Exploring the Link Between Sleep Disturbances and Fatigue in Rheumatoid Arthritis.

Project description: Not available

| S-EPMC12354271 | biostudies-literature

Association between sleep disorders and rheumatoid arthritis in U.S. adults.

Project description: Not available

| S-EPMC12849551 | biostudies-literature