Fast food diet with CCl4 micro-dose induced hepatic-fibrosis--a novel animal model.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is defined as a spectrum of conditions ranging from hepatocellular steatosis to steatohepatitis and fibrosis, progressing to cirrhosis, which occur in the absence of excessive alcohol use. Several animal models capture aspects of NAFLD but are limited either in their representation of the disease stages or use for development of therapeutics due to the extended periods of time required to develop full histological features.

Methods

Here, we report the development of a novel rat model for NAFLD that addresses some of these limitations. We used a fast food diet (FFD) and a CCl4 micro dose (0.5 ml/kg B.wt) for 8 weeks in Wistar rats. Serological analyses, gene expression profiling and liver histology studies were conducted to

SUBMITTER: Chheda TK 

PROVIDER: S-EPMC4036109 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature