Aromatase variants modify risk for Alzheimer's disease in a multiethnic female cohort.

ABSTRACT:

Background/aims

Few studies of gene variants that affect estrogen activity investigate their association with risk for Alzheimer's disease (AD) in women of different ethnicities. We investigated the influence of CYP19 polymorphisms on risk for AD in a multiethnic cohort of women, with individual ethnicity assessed by genetic population ancestry informative markers (AIMs) as well as by self-identified ethnicity.

Methods

Among 1,686 women participating in the Washington Heights Inwood Columbia Aging Project, association with risk for AD was assessed for 41 single nucleotide polymorphisms (SNPs) on the CYP19 gene using multivariable logistic regression, adjusting for age, presence of an APOE ε4 allele, years of education, and body mass index.

Results

Risk for AD was asso

SUBMITTER: Janicki SC 

PROVIDER: S-EPMC4036496 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature