Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes.

ABSTRACT:

Aims/hypothesis

We recently found that activation of the type III histone deacetylase sirtuin 1 suppresses T cell immune responses. Here we sought to determine the therapeutic potential of the sirtuin 1 activator resveratrol in the treatment of diabetes in the NOD mouse model of type 1 diabetes and the mechanisms underlying such potential.

Methods

NOD mice were fed or subcutaneously injected with resveratrol and evaluated for development of diabetes. Splenocytes from resveratrol-treated and control mice were analysed by gene array. The altered expression of inflammatory genes induced by resveratrol was validated and the role of changed gene expression in prevention of diabetes was determined.

Results

Resveratrol administration potently prevented and treated type 1 dia

SUBMITTER: Lee SM 

PROVIDER: S-EPMC4036531 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature