Characterizing the efficacy of fermented wheat germ extract against ovarian cancer and defining the genomic basis of its activity.

ABSTRACT:

Objective

Most women with advanced-stage epithelial ovarian cancer (OVCA) ultimately develop chemoresistant recurrent disease. Therefore, a great need to develop new, more active, and less toxic agents and/or to optimize the efficacy of existing agents exists.

Methods

In this study, we investigated the activity of Avemar, a natural, nontoxic, fermented wheat germ extract (FWGE), against a range of OVCA cell lines, both alone and in combination with cisplatin chemotherapy and delineated the molecular signaling pathways that underlie FWGE activity at a genome-wide level.

Results

We found that FWGE exhibited significant antiproliferative effects against 12 human OVCA cell lines and potentiated cisplatin-induced apoptosis. Pearson correlation of FWGE sensitivity and gene

SUBMITTER: Judson PL 

PROVIDER: S-EPMC4036555 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature