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Topical application of imiquimod as a treatment for chromoblastomycosis.

ABSTRACT: Chromoblastomycosis is a subcutaneous mycosis that remains a therapeutic challenge, with no standard treatment and high rates of relapse. On the basis of our recent discoveries in mouse models, we tested the efficacy of topical applications of imiquimod to treat patients afflicted with this chronic fungal infection. We report results of treatment for the first 4 recipients of topical imiquimod, all of whom displayed a marked improvement of their lesions, both with and without concurrent oral antifungal therapy.

SUBMITTER: de Sousa Mda G 

PROVIDER: S-EPMC4036686 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Topical application of imiquimod as a treatment for chromoblastomycosis.

de Sousa Maria da Glória Teixeira Mda G   Belda Walter W   Spina Ricardo R   Lota Priscila Ramos PR   Valente Neusa Sakai NS   Brown Gordon D GD   Criado Paulo Ricardo PR   Benard Gil G  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20140314 12

Chromoblastomycosis is a subcutaneous mycosis that remains a therapeutic challenge, with no standard treatment and high rates of relapse. On the basis of our recent discoveries in mouse models, we tested the efficacy of topical applications of imiquimod to treat patients afflicted with this chronic fungal infection. We report results of treatment for the first 4 recipients of topical imiquimod, all of whom displayed a marked improvement of their lesions, both with and without concurrent oral ant  ...[more]

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