Dataset Information

Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013.

ABSTRACT: We investigated a case of human infection with Middle East respiratory syndrome coronavirus (MERS-CoV) after exposure to infected camels. Analysis of the whole human-derived virus and 15% of the camel-derived virus sequence yielded nucleotide polymorphism signatures suggestive of cross-species transmission. Camels may act as a direct source of human MERS-CoV infection.

SUBMITTER: Memish ZA

PROVIDER: S-EPMC4036761 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013.

Memish Ziad A ZA Cotten Matthew M Meyer Benjamin B Watson Simon J SJ Alsahafi Abdullah J AJ Al Rabeeah Abdullah A AA Corman Victor Max VM Sieberg Andrea A Makhdoom Hatem Q HQ Assiri Abdullah A Al Masri Malaki M Aldabbagh Souhaib S Bosch Berend-Jan BJ Beer Martin M Müller Marcel A MA Kellam Paul P Drosten Christian C

Emerging infectious diseases 20140601 6

We investigated a case of human infection with Middle East respiratory syndrome coronavirus (MERS-CoV) after exposure to infected camels. Analysis of the whole human-derived virus and 15% of the camel-derived virus sequence yielded nucleotide polymorphism signatures suggestive of cross-species transmission. Camels may act as a direct source of human MERS-CoV infection. ...[more]

PMID: 24857749

Similar Datasets

Project description:Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic disease. Exposure to dromedary camels (Camelus dromedaries) has been consistently considered the main source of primary human infection. Although Saudi Arabia reports the highest rate of human MERS-CoV infection and has one of the largest populations of dromedary camels worldwide, their spatial association has not yet been investigated. Thus, this study aimed to examine the correlation between the spatial distribution of primary MERS-CoV cases with or without a history of camel exposure reported between 2012 and 2019 and dromedary camels at the provincial level in Saudi Arabia. In most provinces, a high proportion of older men develop infections after exposure to camels. Primary human infections during spring and winter were highest in provinces characterized by seasonal breeding and calving, increased camel mobilization and camel-human interactions. A strong and significant association was found between the total number of dromedary camels and the numbers of primary camel-exposed and non-exposed MERS-CoV cases. Furthermore, spatial correlations between MERS-CoV cases and camel sex, age and dairy status were significant. Via a cluster analysis, we identified Riyadh, Makkah and Eastern provinces as having the most primary MERS-CoV cases and the highest number of camels. Transmission of MERS-CoV from camels to humans occurs in most primary cases, but there is still a high proportion of primary infections with an ambiguous link to camels. The results from this study include significant correlations between primary MERS-CoV cases and camel populations in all provinces, regardless of camel exposure history. This supports the hypothesis of the role of an asymptomatic human carrier or, less likely, an unknown animal host that has direct contact with both infected camels and humans. In this study, we performed a preliminary risk assessment of prioritization measures to control the transmission of infection from camels to humans.

Dataset Information

Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013.

Publications

Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets