Developmental origins of pregnancy loss in the adult female common marmoset monkey (Callithrix jacchus).

ABSTRACT:

Background

The impact of the intrauterine environment on the developmental programming of adult female reproductive success is still poorly understood and potentially underestimated. Litter size variation in a nonhuman primate, the common marmoset monkey (Callithrix jacchus), allows us to model the effects of varying intrauterine environments (e.g. nutrient restriction, exposure to male womb-mates) on the risk of losing fetuses in adulthood. Our previous work has characterized the fetuses of triplet pregnancies as experiencing intrauterine nutritional restriction.

Methodology/principal findings

We used over a decade of demographic data from the Southwest National Primate Research Center common marmoset colony. We evaluated differences between twin and triplet females in the

SUBMITTER: Rutherford JN 

PROVIDER: S-EPMC4037172 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature