Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans.

ABSTRACT:

Background

Preclinical evidence implicates the serotonin receptor 5-hydroxytryptamine 1B (5-HT1B) in the effects of cocaine. This study explores 5-HT1B in humans by examining receptor availability in vivo in subjects whose primary addiction is cocaine dependence (CD) using positron emission tomography.

Methods

Study participants included 14 medically healthy subjects with CD (mean age = 41 ± 6 years) who were compared with 14 age-matched healthy control subjects (mean age = 41 ± 8 years) with no past or current history of cocaine or other illicit substance abuse. Participants underwent magnetic resonance imaging followed by positron emission tomography with the highly selective 5-HT1B tracer, [(11)C]P943, for purposes of quantifying regional binding potential. Voxel-based mo

SUBMITTER: Matuskey D 

PROVIDER: S-EPMC4037398 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature