Circulating TSLP associates with decreased wheezing in non-atopic preschool children: data from the URECA birth cohort.

ABSTRACT:

Background

Mouse models of atopic march suggest that systemic, skin-derived thymic stromal lymphopoietin (TSLP) mediates progression from eczema to asthma.

Objective

We investigated whether circulating TSLP is associated with eczema, allergic sensitization, or recurrent wheezing in young children.

Methods

A prospective analysis of the relationship between plasma levels of TSLP to allergic sensitization and recurrent wheezing was conducted in the birth cohort from the Urban Environment and Childhood Asthma (URECA) study. Plasma TSLP levels were measured at 1, 2, and 3 years of age and analysed for correlation with clinical parameters in each of the three years. Only those children with consecutive samples for all three years were included in this analysis.

Results</

SUBMITTER: Demehri S 

PROVIDER: S-EPMC4037448 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature