The immune profile associated with acute allergic asthma accelerates clearance of influenza virus.

ABSTRACT: Asthma was the most common comorbidity in hospitalized patients during the 2009 influenza pandemic. For unknown reasons, hospitalized asthmatics had less severe outcomes and were less likely to die from pandemic influenza. Our data with primary human bronchial cells indicate that changes intrinsic to epithelial cells in asthma may protect against cytopathology induced by influenza virus. To further study influenza virus pathogenesis in allergic hosts, we aimed to develop and characterize murine models of asthma and influenza comorbidity to determine structural, physiological and immunological changes induced by influenza in the context of asthma. Aspergillus fumigatus-sensitized and -challenged C57BL/6 mice were infected with pandemic H1N1 influenza virus, either during peak allergic infla

SUBMITTER: Samarasinghe AE 

PROVIDER: S-EPMC4037497 | biostudies-literature | 2014 May-Jun

REPOSITORIES: biostudies-literature