Early detection and staging of spontaneous embryo resorption by ultrasound biomicroscopy in murine pregnancy.

ABSTRACT:

Background

Embryo resorption is a major problem in human medicine, agricultural animal production and in conservation breeding programs. Underlying mechanisms have been investigated in the well characterised mouse model. However, post mortem studies are limited by the rapid disintegration of embryonic structures. A method to reliably identify embryo resorption in alive animals has not been established yet. In our study we aim to detect embryos undergoing resorption in vivo at the earliest possible stage by ultra-high frequency ultrasound.

Methods

In a longitudinal study, we monitored 30 pregnancies of wild type C57BI/6 mice using ultra-high frequency ultrasound (30-70 MHz), so called ultrasound biomicroscopy (UBM). We compared the sonoembryology of mouse conceptuses under sp

SUBMITTER: Flores LE 

PROVIDER: S-EPMC4037759 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature