Overexpression of KAI1 Protein in Diabetic Skin Tissues.

ABSTRACT:

Background

Patients with diabetes mellitus often have a difficult life, suffering from foot ulceration or amputation. Diabetes is characterized by chronic inflammation, and one of the features of inflammation is hypoxia. Recently, it has been reported that KAI1 is a hypoxia target gene. There is no published research on hypoxia-related KAI1 protein levels in human diabetic skin. Therefore, we have investigated the expression of KAI1 protein in diabetic skin tissue in vivo.

Methods

The expression of KAI1 protein was evaluated by western blotting in 6 diabetic skin tissue samples and 6 normal skin samples. Immunohistochemical staining was carried out to identify KAI1 expression.

Results

The western blotting revealed significantly increased expression of the KAI1 protein

SUBMITTER: Cho MK 

PROVIDER: S-EPMC4037770 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature