Long-term survivor characteristics in HER2-positive metastatic breast cancer from registHER.

ABSTRACT:

Background

Data characterising long-term survivors (LTS) with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) are limited. This analysis describes LTS using registHER observational study data.

Methods

A latent class modelling (LCM) approach was used to identify distinct homogenous patient groups (or classes) based on progression-free survival (PFS), overall survival, and complete response. Demographics, clinicopathologic factors, first-line treatment patterns, and clinical outcomes were described for each class. Class-associated factors were evaluated using logistic regression analysis.

Results

LCM identified two survivor groups labelled as LTS (n=244) and short-term survivors (STS; n=757). Baseline characteristics were similar

SUBMITTER: Yardley DA 

PROVIDER: S-EPMC4037822 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature