Evaluation of safety of A/H1N1 pandemic vaccination during pregnancy: cohort study.

ABSTRACT:

Objective

To assess the risk of maternal, fetal, and neonatal outcomes associated with the administration of an MF59 adjuvanted A/H1N1 vaccine during pregnancy.

Design

Historical cohort study.

Setting

Singleton pregnancies of the resident population of the Lombardy region of Italy.

Participants

All deliveries between 1 October 2009 and 30 September 2010. Data on exposure to A/H1N1 pandemic vaccine, pregnancy, and birth outcomes were retrieved from regional databases. Vaccinated and non-vaccinated women were compared in a propensity score matched analysis to estimate risks of adverse outcomes.

Main outcome measures

Main maternal outcomes included type of delivery, admission to intensive care unit, eclampsia, and gestational diabetes; fetal and neonatal ou

SUBMITTER: Trotta F 

PROVIDER: S-EPMC4038133 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature