Different effects of whole-cell and acellular vaccines on Bordetella transmission.

ABSTRACT:

Background

Vaccine development has largely focused on the ability of vaccines to reduce disease in individual hosts, with less attention to assessing the vaccine's effects on transmission between hosts. Current acellular vaccines against Bordetella pertussis are effective in preventing severe disease but have little effect on less severe coughing illness that can mediate transmission.

Methods

Using mice that are natural host's of Bordetella bronchiseptica, we determined the effects of vaccination on shedding and transmission of this pathogen.

Results

Vaccination with heat-killed whole-cell B. bronchiseptica or B. pertussis inhibited shedding of B. bronchiseptica. Differences in neutrophil and B-cell recruitment distinguished sham-vaccine from whole-cell-----vaccine re

SUBMITTER: Smallridge WE 

PROVIDER: S-EPMC4038146 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature