Hydroxyurea is associated with lower prevalence of albuminuria in adults with sickle cell disease.

ABSTRACT:

Background

Albuminuria is an early manifestation of sickle cell nephropathy. Prior small case series suggests benefit of hydroxyurea in reducing albuminuria, with a similar trend noted in pediatric studies. We aimed to comprehensively evaluate hydroxyurea use and prevalence of albuminuria in adult sickle cell patients.

Methods

We performed a cross-sectional study of 149 adult patients followed between 2000 and 2011 in a comprehensive sickle cell clinic. All patients were assessed for albuminuria either by direct measurement or by urinary chemical strip (dipstick) testing. Urinary albumin-to-creatinine ratios (UACRs) were available for 112 patients. Hydroxyurea exposure was defined as ≥3 months of therapy before the assessment of albuminuria. Albuminuria was defined as either

SUBMITTER: Laurin LP 

PROVIDER: S-EPMC4038249 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature