Higher potency statins and the risk of new diabetes: multicentre, observational study of administrative databases.

ABSTRACT:

Objective

To evaluate the incremental increase in new onset diabetes from higher potency statins compared with lower potency statins when used for secondary prevention.

Design

Eight population based cohort studies and a meta-analysis.

Setting

Six Canadian provinces and two international databases from the UK and US.

Participants

136,966 patients aged ≥ 40 years newly treated with statins between 1 January 1997 and 31 March 2011.

Methods

Within each cohort of patients newly prescribed a statin after hospitalisation for a major cardiovascular event or procedure, we performed as-treated, nested case-control analyses to compare diabetes incidence in users of higher potency statins with incidence in users of lower potency statins. Rate ratios of new diabetes

SUBMITTER: Dormuth CR 

PROVIDER: S-EPMC4038449 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature