Cingulate metabolites during pain and morphine treatment as assessed by magnetic resonance spectroscopy.

ABSTRACT:

Background

Experimental investigation of cerebral mechanisms underlying pain and analgesia are important in the development of methods for diagnosis and treatment of pain. The aim of the current study was to explore brain metabolites in response to pain and treatment with morphine.

Methods

Proton magnetic resonance spectroscopy of the anterior cingulate cortex was performed in 20 healthy volunteers (13 males and seven females, aged 24.9±2.6 years) during rest and acute pain before and during treatment with 30 mg of oral morphine or placebo in a randomized, double-blinded, cross-over study design. Pain was evoked by skin stimulation applied to the right upper leg using a contact heat-evoked potential stimulator.

Results

Data from 12 subjects were valid for analysis. Pa

SUBMITTER: Hansen TM 

PROVIDER: S-EPMC4038455 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature