Altered behavior in mice with deletion of the alpha2-antiplasmin gene.

ABSTRACT:

Background

The α2-antiplasmin (α2AP) protein is known to be a principal physiological inhibitor of plasmin, and is expressed in various part of the brain, including the hippocampus, cortex, hypothalamus and cerebellum, thus suggesting a potential role for α2AP in brain functions. However, the involvement of α2AP in brain functions is currently unclear.

Objectives

The goal of this study was to investigate the effects of the deletion of the α2AP gene on the behavior of mice.

Methods

The motor function was examined by the wire hang test and rotarod test. To evaluate the cognitive function, a repeated rotarod test, Y-maze test, Morris water maze test, passive or shuttle avoidance test and fear conditioning test were performed. An open field test, dark/light transition tes

SUBMITTER: Kawashita E 

PROVIDER: S-EPMC4038522 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature