Ontology highlight
ABSTRACT:
SUBMITTER: Aydin I
PROVIDER: S-EPMC4038628 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
PLoS pathogens 20140529 5
A two-step, high-throughput RNAi silencing screen was used to identify host cell factors required during human papillomavirus type 16 (HPV16) infection. Analysis of validated hits implicated a cluster of mitotic genes and revealed a previously undetermined mechanism for import of the viral DNA (vDNA) into the nucleus. In interphase cells, viruses were endocytosed, routed to the perinuclear area, and uncoated, but the vDNA failed to be imported into the nucleus. Upon nuclear envelope perforation ...[more]