Cellular origins of auditory event-related potential deficits in Rett syndrome.

ABSTRACT: Dysfunction in sensory information processing is a hallmark of many neurological disorders, including autism spectrum disorders, schizophrenia and Rett syndrome (RTT). Using mouse models of RTT, a monogenic disorder caused by mutations in MECP2, we found that the large-scale loss of MeCP2 from forebrain GABAergic interneurons led to deficits in auditory event-related potentials and seizure manifestation, whereas the restoration of MeCP2 in specific classes of interneurons ameliorated these deficits.

SUBMITTER: Goffin D 

PROVIDER: S-EPMC4038660 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature