Clinical and genetic determinants of progression of type 2 diabetes: a DIRECT study.

ABSTRACT:

Objective

To identify the clinical and genetic factors that explain why the rate of diabetes progression is highly variable between individuals following diagnosis of type 2 diabetes.

Research design and methods

We studied 5,250 patients with type 2 diabetes using comprehensive electronic medical records in Tayside, Scotland, from 1992 onward. We investigated the association of clinical, biochemical, and genetic factors with the risk of progression of type 2 diabetes from diagnosis to the requirement of insulin treatment (defined as insulin treatment or HbA1c ≥8.5% [69 mmol/mol] treated with two or more noninsulin therapies).

Results

Risk of progression was associated with both low and high BMI. In an analysis stratified by BMI and HbA1c at diagnosis, faster progressi

SUBMITTER: Zhou K 

PROVIDER: S-EPMC4038744 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature