Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.

ABSTRACT:

Background

Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.

Methods

In this GCTA study, we obtained data about HbA1c concentrations before and during metformin treatment from patients in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) study, which includes a cohort of patients with type 2 diabetes and is linked to comprehensive clinical databases and genome-wide association study data. We applied the GCTA

SUBMITTER: Zhou K 

PROVIDER: S-EPMC4038749 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature