Significant gender difference in serum levels of fibroblast growth factor 21 in Danish children and adolescents.

ABSTRACT:

Introduction

Fibroblast Growth Factor 21 (FGF21) is a novel metabolic factor with effect on glucose and lipid metabolism, and shown to be elevated in diseases related to metabolic syndrome. Due to the increasing frequency of metabolic syndrome in the pediatric population, and as FGF21 studies in children are limited, we investigated baseline serum levels of FGF21 in healthy children during an oral glucose tolerance test.

Methods

A total of 179 children and adolescents from the COPENHAGEN Puberty Study were included. An OGTT with glucose and insulin measurements, a dual energy X-ray absorptiometry (DXA) scan and a clinical examination including pubertal staging were done on all subjects. Serum levels of FGF21, adiponectin, and leptin were determined by immunoassays at baselin

SUBMITTER: Bisgaard A 

PROVIDER: S-EPMC4039053 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature