Bioinformatics for precision medicine in oncology: principles and application to the SHIVA clinical trial.

ABSTRACT: Precision medicine (PM) requires the delivery of individually adapted medical care based on the genetic characteristics of each patient and his/her tumor. The last decade witnessed the development of high-throughput technologies such as microarrays and next-generation sequencing which paved the way to PM in the field of oncology. While the cost of these technologies decreases, we are facing an exponential increase in the amount of data produced. Our ability to use this information in daily practice relies strongly on the availability of an efficient bioinformatics system that assists in the translation of knowledge from the bench towards molecular targeting and diagnosis. Clinical trials and routine diagnoses constitute different approaches, both requiring a strong bioinformatics environme

SUBMITTER: Servant N 

PROVIDER: S-EPMC4039073 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature