Cost-effectiveness of blood donor screening for Babesia microti in endemic regions of the United States.

ABSTRACT:

Background

Babesia microti is the leading reported cause of red blood cell (RBC) transfusion-transmitted infection in the United States. Donor screening assays are in development.

Study design and methods

A decision analytic model estimated the cost-effectiveness of screening strategies for preventing transfusion-transmitted babesiosis (TTB) in a hypothetical cohort of transfusion recipients in Babesia-endemic areas of the United States. Strategies included: 1) no screening; 2) Uniform Donor Health History Questionnaire (UDHQ), "status quo"; 3) recipient risk targeting using donor antibody and polymerase chain reaction (PCR) screening; 4) universal endemic donor antibody screening; and 5) universal endemic donor antibody and PCR screening. Outcome measures were TTB cases ave

SUBMITTER: Simon MS 

PROVIDER: S-EPMC4039174 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature