Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators.

ABSTRACT:

Background

A growing body of research shows that mindfulness meditation can alter neural, behavioral and biochemical processes. However, the mechanisms responsible for such clinically relevant effects remain elusive.

Methods

Here we explored the impact of a day of intensive practice of mindfulness meditation in experienced subjects (n=19) on the expression of circadian, chromatin modulatory and inflammatory genes in peripheral blood mononuclear cells (PBMC). In parallel, we analyzed a control group of subjects with no meditation experience who engaged in leisure activities in the same environment (n=21). PBMC from all participants were obtained before (t1) and after (t2) the intervention (t2-t1=8h) and gene expression was analyzed using custom pathway focused quantitative-re

SUBMITTER: Kaliman P 

PROVIDER: S-EPMC4039194 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature