Association of Parkinson disease risk loci with mild parkinsonian signs in older persons.

ABSTRACT:

Importance

Parkinsonian motor signs are common in the aging population and are associated with adverse health outcomes. Compared with Parkinson disease (PD), potential genetic risk factors for mild parkinsonian signs have been largely unexplored.

Objective

To determine whether PD susceptibility loci are associated with parkinsonism or substantia nigra pathology in a large community-based cohort of older persons.

Design, setting, and participants

Eighteen candidate single-nucleotide polymorphisms from PD genome-wide association studies were evaluated in a joint clinicopathologic cohort. Participants included 1698 individuals and a nested autopsy collection of 821 brains from the Religious Orders Study and the Rush Memory and Aging Project, 2 prospective community-based

SUBMITTER: Shulman JM 

PROVIDER: S-EPMC4039209 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature