The selective control of glycolysis, gluconeogenesis and glycogenesis by temporal insulin patterns.

ABSTRACT: Insulin governs systemic glucose metabolism, including glycolysis, gluconeogenesis and glycogenesis, through temporal change and absolute concentration. However, how insulin-signalling pathway selectively regulates glycolysis, gluconeogenesis and glycogenesis remains to be elucidated. To address this issue, we experimentally measured metabolites in glucose metabolism in response to insulin. Step stimulation of insulin induced transient response of glycolysis and glycogenesis, and sustained response of gluconeogenesis and extracellular glucose concentration (GLC(ex)). Based on the experimental results, we constructed a simple computational model that characterises response of insulin-signalling-dependent glucose metabolism. The model revealed that the network motifs of glycolysis and glycog

SUBMITTER: Noguchi R 

PROVIDER: S-EPMC4039368 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature