Likelihood-Based Approach to Gene Set Enrichment Analysis with a Finite Mixture Model.

ABSTRACT: In this paper, we study a parametric modeling approach to gene set enrichment analysis. Existing methods have largely relied on nonparametric approaches employing, e.g., categorization, permutation or resampling-based significance analysis methods. These methods have proven useful yet might not be powerful. By formulating the enrichment analysis into a model comparison problem, we adopt the likelihood ratio-based testing approach to assess significance of enrichment. Through simulation studies and application to gene expression data, we will illustrate the competitive performance of the proposed method.

SUBMITTER: Lee SM 

PROVIDER: S-EPMC4039382 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature