Rif1 regulates initiation timing of late replication origins throughout the S. cerevisiae genome.

ABSTRACT: Chromosomal DNA replication involves the coordinated activity of hundreds to thousands of replication origins. Individual replication origins are subject to epigenetic regulation of their activity during S-phase, resulting in differential efficiencies and timings of replication initiation during S-phase. This regulation is thought to involve chromatin structure and organization into timing domains with differential ability to recruit limiting replication factors. Rif1 has recently been identified as a genome-wide regulator of replication timing in fission yeast and in mammalian cells. However, previous studies in budding yeast have suggested that Rif1's role in controlling replication timing may be limited to subtelomeric domains and derives from its established role in telomere length reg

SUBMITTER: Peace JM 

PROVIDER: S-EPMC4039536 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature